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Figure 3 (A) Changes in heart rate following drug administration. (B) Changes in ventricular effective refractory periods following drug administration. (C) Changes in T-wave alternans (TWA) amplitude following drug administration (V_alt) in patients with d,l-sotalol (dark bars) and metoprolol (gray bars). (D) Representative example of a patient with a significant decrease in V_alt in nearly all electrocardiographic leads following administration of d,l-sotalol (left: before drug administration; right: after drug administration). BPM = beats per minute; HR = heart rate.