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Figure 2 Relationship of flow-mediated vasodilation (FMV) and serum uric acid level (SUA) with degree of cardiovascular disease (CVD) risk. There is a stepwise decrease in FMV and a stepwise increase in SUA with increasing risk. Regression plot of mean values for each risk group forms is nearly linear. The four risk groups are: I = those with no disease or risk factors for cardiovascular disease; II = those with one or more risk factors but no CVD identified by history, physical examination, laboratory analysis or review of medical records; III = those with a diagnosis of CVD but without events; IV = those with a history of events including myocardial infarction and stroke. Values are mean ± SEM. **p < 0.01; ***p < 0.001 for FMV and {dagger}p < 0.05; {dagger}{dagger}p < 0.01 for SUA.