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Figure 4 Data from one animal with anterior transmural infarction. (a) Shows the color Doppler myocardial imaging (DMI) frame during the isovolumic contraction phase and the location of sample in pulsed DMI mode; epicardial markers are located at the tip of the arrows. (b) Corresponding 2,3,5-triphenyltetrazolium chloride and Evans blue-stained cardiac specimen image. (c) Pulsed and color M-mode DMI at baseline, at the end of the occlusion (120 min) and after reperfusion (30 min) in the ischemic and nonischemic regions (pulsed DMI). Note in the ischemic region the reduced, but present, velocities during the ejection (S) (suggesting tethering effect) but different patterns of isovolumic contraction (IVC) velocities (red arrows), which clearly identify ischemic myocardium. No change occurred in the nonischemic region. The dashed vertical lines indicate the time of the aortic valve opening and closure. E = myocardial velocity due to early left ventricular filling; PSC = tissue velocities due to postsystolic contraction.