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Figure 3 Data from one animal with a small anterior infarct. (a) A color Doppler myocardial imaging (DMI) frame during isovolumic contraction phase and showing the location of sample in pulsed DMI mode; epicardial markers are located at the tip of the arrows. (b) Shows a corresponding stained cardiac specimen image. The transmural extent of necrosis measured at the location of the sample gate was 6%. (c) Pulsed and color M-mode DMI at baseline, at the end of the occlusion (60 min) and after reperfusion (30 min). Note the reduced systolic (S) velocities during the ejection phase but the presence of high positive isovolumic contraction (IVC) velocity (red arrows), identifying ischemic, but viable, myocardium. The dashed vertical lines indicate the time of the aortic valve opening and closure.