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Figure 4 Effect of anti-interleukin-1 (IL-1) treatment (monoclonal antibody) on the progression of left ventricular (LV) remodeling. Neutralization of IL-1ß in the acute phase of myocardial infarction significantly increased total heart weight and LV end-diastolic dimension (LVEDD). There was no significant difference between the vehicle-treated and control (immunoglobulin G [IgG]-treated) groups (four mice in each). n.s. = not significant.