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Figure 3 Immunohistochemical staining of the myocardium from a Dahl-SS rat with type I collagen in the LV (control rat, upper left), an untreated rat (diastolic heart failure [DHF], upper right) and a rat treated with high-dose amlodipine ( administered amlodipine of high dose [HDA], lower left) and low-dose amlodipine (administered amlodipine of low dose [LDA]) at 19 weeks. An increase in type I collagen was observed in the DHF rat as compared with the control rat. A visible reduction in the level of type I collagen was noted in the order of the control, high-dose amlodipine and low-dose amlodipine rats.