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Figure 2 Hydroxyproline content of the left venticle (Pro-OH) and the ratio of type I to type III collagen mRNA levels (collagen I/III ratio) in the control, diastolic heart failure (DHF), high-dose amlodipine (administered amlodipine of high dose [HDA]) and low-dose amlodipine (administered amlodipine of low dose [LDA]) groups in the heart failure stage at 19 weeks (upper). *p < 0.05 vs. control group; #p < 0.05 vs. DHF group. The correlation between myocardial stiffness constant (MSC) and Pro-OH or the collagen I/III ratio was determined in pooled data taken from all of the rats (n = 22) (lower).