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Figure 2 ST segment resolution 180 min after administration of therapy and mortality (at time points between 21 to 35 days) in four trials of thrombolytic therapy in acute myocardial infarction. All studies found statistically significant mortality differences between the three groups of ST resolution. GUSTO-III = Global Use of Strategies to Open Occluded Coronary Arteries study; HIT-4 = Hirudin for Improvement of Thrombolysis (HIT)-4 study; INJECT = International Joint Efficacy Comparison of Thrombolytics study; ISAM = Intravenous Streptokinase in Acute Myocardial Infarction. Data abstracted from references 12, 13 and 40. The GUSTO-III data are abstracted from Anderson R, White H, Ohmann E, et al. Resolution of ST segment elevation 90 minutes after thrombolysis for acute myocardial infarction predicts outcome: a GUSTO III substudy (abstr). J Am Coll Cardiol 1998;31 Suppl A:371A.