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Figure 2 Transforming growth factor-beta 1 (TGF-beta 1) messenger ribonucleic acid (mRNA) expression in different regions of the heart two weeks after acute myocardial infarction (AMI). Reverse transcription polymerase chain reaction was performed for RNA extracted from noninfarcted septum of the left ventricle and the right ventricle after AMI. In the noninfarcted septum, there was about twofold increase in TGF-beta 1 mRNA after AMI. Treatment with fosinopril (Fos) significantly decreased the amount of TGF-beta 1 mRNA expression in this region, while valsartan or a combination of fosinopril and valsartan (Fos + Val) normalized its expression. In the right ventricle, there was no significant change in TGF-beta 1 mRNA in any group. M = {phi}X174/HaeIII marker; Sham = sham-operated rats.