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Figure 1 Immunolocalization of activated cardiac myofibroblasts (A to E) and macrophages (F to J) in the infarct region two weeks after acute myocardial infarction (AMI). The activated myofibroblasts and macrophages were stained dark brown by anti-alpha-smooth muscle actin and anti-ED-1 antibodies, respectively. There was significant infiltration of activated myofibroblasts (B) and macrophages (G) after AMI that were not seen in the sham-operated rats (A and F). Treatment with fosinopril (C) decreased the infiltration of activated myofibroblasts, but not the macrophages (H). On the other hand, valsartan (D and I) and combined therapy of fosinopril and valsartan (E and J) significantly reduced the number of activated myofibroblasts and macrophages in the infarct zone (magnification 400x).