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Figure 5 Role of norepinephrine and epinephrine in regulating activation of the renin-angiotensin system after aortic constriction. The renal renin messenger ribonucleic acid (mRNA) level was significantly increased in the banded control mice compared with the sham-operated mice, but not in the banded Dbh^–/– mice. *p < 0.001 for sham operation control group vs. TAC control group; p = NS for sham operation Dbh^–/– group vs. TAC Dbh^–/– group. Sham operation: n = 6 in control group and n = 4 in Dbh^–/– group; TAC: n = 4 in control group and n = 6 in Dbh^–/– group.