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Figure 3 Effect of pressure overload on activation of MAPK pathways. Representative autoradiograms and summary data of MAPK activity for each of the three major pathways are shown. (a) ERK 1/2: *p < 0.0005 for sham operation control group vs. TAC control group. (b) JNK 1/2: *p < 0.0001 for sham operation control group vs. TAC control group. (c) p38: *p < 0.0005 for sham operation control group vs. TAC control group. (d) p38ß: *p < 0.001 for sham operation control group vs. TAC control group. p = NS for sham operation Dbh^–/– group vs. TAC Dbh^–/– group for the aforementioned MAPKs.