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Figure 1 Effect of pressure overload on development of cardiac hypertrophy in control and Dbh^–/– mice. (a) The LVW/BW ratio was measured in control and Dbh^–/– mice seven days after either a sham operation or TAC. *p < 0.00001 for TAC control group vs. sham operation control group. p < 0.005 for TAC control group vs. TAC Dbh^–/– group. p < 0.01 for TAC Dbh^–/– group vs. sham operation Dbh^–/– group. (b) The LVW/TL ratio was used as an index of the hypertrophic response after TAC. *p < 0.001 for TAC control group vs. either sham operation control group or TAC Dbh^–/– group. Sham operation control group (n = 12); TAC control group (n = 13); sham operation Dbh^–/– group (n = 13); and TAC Dbh^–/– group (n = 11). Data are from the control and Dbh^–/– mice with pressure gradients >40 mm Hg.