Click on image to view larger version.

Figure 4 Representative carotid Doppler flow recordings obtained from a rabbit after local treatment of one carotid artery with retro-tissue factor pathway inhibitor (TFPI) and the other one with retro-green fluorescent protein (GFP). At baseline (i.e., before induction of the recombinant proteins), cyclic flow variations (CFVs) developed similarly in both carotid arteries. In contrast, 2 h after induction with doxycycline (3 mg/kg intravenous bolus plus 300 µg/kg per min), CFVs were completely inhibited only in the carotid artery previously transfected with retro-TFPI, although they remained unchanged in the vessel previously transfected with retro-GFP.