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Figure 1 (A) Relationship between circulating growth hormone (GH) and insulin-like growth factor-I (IGF-I) levels (log IGF-I/GH ratio) in patients with chronic heart failure (CHF) and healthy control subjects. (B) Relationship between functionally intact GH-binding protein (BP) and the log IGF-I/GH ratio. Data are from study 1 and are presented as the mean value ± SD. *p < 0.0001; **p = 0.0001 vs. cachectic patients with CHF.