Click on image to view larger version.

Figure 3 Effect of enalaprilat (Enal, triangles) and N^G-monomethyl-L-arginine (L-NMMA) (diamonds) on the end-diastolic pressure-volume relationship (EDPVR) in the presence of dobutamine (Dob, squares) in patients with DCM (Groups I and II) and subjects with normal left ventricular function (Group III). Depicted are representative steady state end-diastolic pressure-volume data. The numbers in parentheses represent the order of drug infusion for each group. In Group I, enalaprilat resulted in a downward shift of the EDPVR, an effect reversed by subsequent L-NMMA co-infusion. In Group II, L-NMMA prevented the EDPVR reduction to enalaprilat. Enalaprilat had no effect on EDPVR in Group III.