Click on image to view larger version.

Figure 1 Representative steady state pressure-volume data. Depicted are the effects of intracoronary enalaprilat and N^G-monomethyl-L-arginine (L-NMMA) on beta-adrenergic contractility, as assessed by single-beat ventricular elastance (E_es). Group I (with dilated cardiomyopathy [DCM]) and Group III (normal subjects) received enalaprilat before L-NMMA. Group II (with DCM) received L-NMMA before enalaprilat. In each group, baseline E_es values are shown as a dashed line. Pressure-volume loops and E_es values are shown at baseline (circles) and in the presence of dobutamine (Dob, squares), enalaprilat (Enal, triangles) and L-NMMA (diamonds). The numbers in parentheses represent the order of drug infusion.