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Figure 4 Haplotypes across the myosin-binding protein C gene (MYBPC3) locus associated with the IVS7+1G>A mutation are shown. The disease-associated haplotypes of the family members of patients 1331 and 169 are boxed. The marker loci used for haplotype construction, covering a distance of 0.6 cM, are indicated at the left, in telomeric-centromeric order, from top to bottom.