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Figure 3 In situ hybridization for angiotensinogen (AGTN) (A,D,G), angiotensin-converting enzyme (ACE) (B,E,H), Glyceraldeyde-3-phosphate dehydrogenase (C,I) and plasmid vector pB322 (F) in controls (A,B,C) and in patients with unstable (D,E,F) and stable (G,H,I) angina. Magnification x 400. Positive messenger RNA (mRNA) signal for AGTN (D) and ACE mRNA (E) was detectable in the interstitial and endothelial cells of patients with unstable angina. On the contrary, mRNA for AGTN (G) and for ACE (H) was not expressed in myocardial biopsy specimens from patients with stable effort angina.