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Figure 3 Effects of chronic treatment with the angiotensin-converting enzyme inhibitor ramipril (1 mg/kg/day), the AT₁ receptor antagonist valsartan (10 mg/kg/day) and the AT₂ receptor antagonist PD 123319 (30 mg/kg/day) on messenger RNA (mRNA) expression of Na⁺-H⁺ exchanger isoform-1 (NHE-1) (A) and Na⁺-HCO₃^– symporter isoform-1 (NBC-1) (B) in the left ventricular free wall one day and seven days after myocardial infarction (MI) compared with sham-operated and placebo-treated animals with MI. *p < 0.05 compared with sham operation; #p < 0.05 compared with placebo MI. Data represent mean ± SEM, n = 6.