Click on image to view larger version.

Figure 2 Egtazic acid (EGTA) during demand ischemia. Ischemia (decreasing coronary perfusion pressure [CPP] to 20 mm Hg) reduced left ventricular systolic pressure (LVSP) to 68 mm Hg and left ventricular end-diastolic pressure (LVEDP) to 15 mm Hg. Tachycardia increased LVEDP to 21 mm Hg, indicating increased diastolic chamber stiffness. An 8 mmol/L EGTA (8 mM) imposed after tachycardia during sustained ischemic diastolic dysfunction reduced LVSP from 70 to 48 mm Hg, indicating reduced intracellular calcium concentration but did not decrease elevated LVEDP, suggesting that this was not calcium-driven. Contractile function recovered after termination of EGTA.