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Figure 3 Peak diastolic coronary artery blood flow rate (A) and coronary artery cross-sectional area (B) during intracoronary infusion of 10 nmol/min of U-46619 alone, combined breathing of 20 ppm nitric oxide (NO) with intravenous infusion of zaprinast (ZAP) (1.0 mg/kg over 4 min, followed by a continuous infusion of 0.05 mg/kg per min) and simultaneous breathing of 20 ppm NO with intravenous infusion of zaprinast or intravenous infusion of 1 µg/kg per min sodium nitroprusside (SNP). Data are mean ± SEM and expressed as percent coronary flow or area before administration of U-46619. *p < 0.05 versus U-46619 alone.