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Figure 1 Schematic representation of the coronary artery patency status in each of four dogs during three sequential 45-min observation periods (pre-treatment, intra-treatment and post-treatment). During the treatment period, the dogs were either untreated (control), breathed 20 ppm nitric oxide (NO), received zaprinast (1.0 mg/kg intravenously over 4 min, followed by a continuous infusion of 0.05 mg/kg per min), received dipyridamole (0.15 mg/kg intravenously over 4 min, followed by a continuous infusion of 0.004 mg/kg per min), received NO plus zaprinast or received NO plus dipyridamole. White areas of bars represent coronary patency (flow >25% of immediate post-constriction flow), and black areas represent occlusion.