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Figure 2 Percentage change in forearm blood flow in response to infusion of 5 pmol/min of endothelin-1 (ET-1) for 60 min after one month of randomized treatment. Compared with the placebo group, the estradiol group showed blunted vasoconstrictor response to ET-1 vasoconstriction in response to ET-1 (p = 0.041). Forearm blood flow is presented as in Figure 1.