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Figure 1 Percentage change in forearm blood flow in response to infusion of 5 pmol/min of endothelin-1 (ET-1) for 60 min before randomization to either placebo or estradiol. Four measurements of forearm blood flow were made before infusion of ET-1 (–30, –15, –1 and 0 min). The last time point (0 min) was taken as baseline. The figure shows subsequent percent change in forearm blood flow during 60 min of ET-1 infusion in each treatment group (placebo or estradiol). There was no difference between the two treatments (p = 0.67).