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Figure 1 Effects of cariporide on the time-course of the regional thickening fraction during repetitive ischemia and reperfusion. The thickening fraction after reperfusion was higher in the cariporide group than it was in the control group (Panel A) (p = 0.010 for group comparison and p < 0.001 for interaction). *p < 0.05 versus data at the corresponding time points. There was no significant difference in the time-courses of thickening fraction between the glib and glib/cariporide groups (Panel B) or between the 5-HD and 5-HD/cariporide groups (Panel C). Glib = glibenclamide; O1, O2, O3, O4 and O5 = first, second, third, fourth and fifth coronary occlusions, respectively; TF (% baseline) = the thickening fraction expressed as a percentage of baseline values; 5-HD = 5-hydroxydecanoate; Tx = treatment.