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Figure 4 Cumulative meta-analysis of OR plots (logarithmic scale) for major bleeding according to whether assigned to antiplatelet therapy or control. The center of each line represents the OR for the cumulative trials with the ends of the horizontal line representing the 95% confidence interval. The solid line represents an OR of 1; to the left of the line (OR < 1) favors antiplatelet therapy, and to the right of the line (OR > 1) favors control or placebo. p values are provided for the accumulated trials once conventional statistical significance (p < 0.05) was achieved. OR = odds ratio.