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Figure 3 Odds ratio plots (logarithmic scale) for major bleeding according to whether assigned to antiplatetet therapy or control. Data for major bleeding was available for only eight of the trials. The center of each line represents the OR for the individual trials and subgroups with the ends of the horizontal line representing the 95% CI. The solid line represents an OR of 1; to the left of the line (OR < 1) favors antiplatelet therapy, and to the right of the line (OR > 1) favors control or placebo. Statistically significant tests of heterogeneity comparing pre- and post-1990 and early and late aspirin trials are shown. The broken line and the center of the box represent the pooled OR, and the ends of the horizontal line represent the pooled 95% CI. CI = confidence interval; OR = odds ratio.