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Figure 4 Serum levels of superoxide (ng/mg) were measured in subjects with known coronary artery disease (CAD) by the lucigenin chemiluminescence assay. Diamonds represent the change in TNF{alpha}-RII levels over the 24-week study period at intervals of 0, 4, 12 and 24 weeks in patients with CAD treated with irbesartan. Squares represent superoxide levels measured in control patients over the study period at the same interval schedule. Values for CAD patient group represent mean ± SD. * = value differs (p < 0.01) from the control group. # = value differs (p < 0.01) from the CAD group before treatment with irbesartan. {diamondsuit} = CAD; {blacksquare} = control.