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Figure 3 Serum levels of TNF{alpha}-RII (ng/dl) were measured in subjects with known coronary artery disease (CAD) by enzyme-linked immunosorbent assay technique. Diamonds represent the change in TNF{alpha}-RII levels over the 24-week study period at intervals of 0, 4, 12 and 24 weeks in patients with CAD treated with irbesartan. Squares represent TNF{alpha}-RII levels measured in control patients over the study period at the same interval schedule. Values for CAD patient group represent mean ± SD. * = value differs (p < 0.001) from the control group. # = value differs (p < 0.001) from the CAD group before treatment with irbesartan. {diamondsuit} = CAD; {blacksquare} = control.