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Figure 3 Effect of losartan on Ang-II-induced TNF-alpha production in rat cardiac myocyte culture. No TNF was measured in the supernatant of untreated cultures, serving as the control group (n = 5). Incubation with 10 and 50 nmol/liter of Ang-II caused significant, dose-dependent TNF-alpha release from myocytes. Preincubation with 350 or 700 µmol/liter of losartan (n = 5 in each group) decreased or abolished the observed Ang-II-induced TNF-alpha release.