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Figure 3 Representative tracings and coronary angiograms from a pig in the ED group at (a) week 0 (before endothelial denudation) and (b) week 8 (2 weeks after four denudations). Coronary blood flow at week 8 initially decreased to zero flow, and subsequent reactive hyperemia appeared with ECG ST depression in limb lead III after intracoronary administration of 0.05 µg/kg acetylcholine (ACh) without showing epicardial coronary artery vasoconstriction. BP = aortic blood pressure; CBF = coronary blood flow in LAD; ECG = electrocardiogram.