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Figure 2 Scatterplots showing the relation between the averaged values of external elastic membrane (EEM) cross-sectional area (CSA)-to-lumen CSA ratios, and the averaged values of vessel diameter in the Control group (a), the ED group (b) and the Drug group (c). Each point in the plot represents the average of vessels in a 10 µm range of diameters in an individual pig. In the Control and Drug groups, the ratios are relatively constant in coronary arteries of various diameters from 10 to 200 µm, and there was no significant correlation between the averaged values of EEM CSA-to-lumen CSA ratios and the vessel diameters. In the ED group, a significant correlation existed between the EEM CSA-to-lumen CSA ratios and the vessel diameters (y = –0.0001x² + 0.0230x + 1.6921, r² = 0.208, p = 0.006).