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Figure 5 The mRNA levels of ppET-1, ECE, ET type A receptor and ET type B receptor at 13 and 19 weeks. Each mRNA level was corrected for an mRNA level of glyceraldehyde-3-phosphate-dehydrogenase and was then normalized to a mean value of the age-matched control group, respectively. *p < 0.05; **p < 0.01 versus control group; p < 0.05; p < 0.01 versus CAND(–) group. Values are means ± SEM. ECE = endothelin-converting enzyme; ET = endothelin; ppET-1 = prepro endothelin-1.