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Figure 5 Activated partial thromboplastin time monitoring during TFPI treatment. Activated partial thromboplastin time values at baseline and different times over a 72-h period after angioplasty for the three treatment groups (UFH plus ASA, heparin bolus plus aspirin; UFH plus ASA plus TFPI, heparin bolus plus ASA plus TFPI; ASA plus TFPI, ASA plus rTFPI). Note the synergistic anticoagulant effect of TFPI and heparin compared with the modest increase in aPTT elicited by TFPI alone. Long-dash line = UFH+ASA; solid line = UFH+ASA+TFPI; short-dash line = ASA+TFPI. aPTT = activated partial thromboplastin time; ASA = acetyl salicylic acid; PTCA = percutaneous transluminal coronary angioplasty; TFPI = tissue factor pathway inhibitor; UFH = unfractionated heparin.