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Figure 4 Effect of carvedilol on TNF-alpha–induced MAPK activation in HUVECs. A, Activity of JNK and (B) phosphorylation of p38 after stimulation with TNF-alpha (50 ng/ml) in the presence or absence of carvedilol (5 µmol/liter). Anisomycin-treated and native C-6 glioma cell extracts as positive and negative control studies, respectively. Representative blots, out of three experiments, are shown.