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Figure 2 Platelet glycoprotein IIb/IIIa structure and function. Heterodimeric structure with cation binding sites, RGD, KGD and KQAGDV binding sites and intracellular tail mediating both inside-to-outside and outside-to-inside signaling. Inside-out signals lead to increased platelet glycoprotein IIb/IIIa receptor activation, while outside-in signals increase ligand-induced binding site (LIBS) expression and cytoskeletal responses.