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Figure 4 Nasal administration of CM reduced the serum levels of total IgE antibodies. Sera were collected on days 10 and 21 from mice that received CM intranasally (right bars, n = 9) and those that received vehicle buffer (left bars, n = 14). The serum levels of total IgE antibodies (ng/ml) were measured by a capture ELISA and presented as the mean of each group ± SEM. The levels of IgE were lower in mice that received CM intranasally on both days 10 and 21, compared to those that received buffer. The decrease in IgE levels on day 10 was statistically significant (p = 0.01).