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Figure 3 Nasal administration of CM did not reduce the production of TGF-ß by splenocytes in response to CM. The splenocytes from mice that received either CM (right bar, n = 4) or vehicle buffer (left bar, n = 3) intranasally were cultured in vitro in the presence of CM (10 µg/ml). The levels of TGF-ß produced in the culture supernatant were measured and presented as the mean of each group ± SEM. There was no decrease in the levels of TGF-ß observed in mice that received CM nasally as compared to those that received buffer nasally.