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Figure 1 The relation between risk of CHD events and LDL levels achieved with statin therapy in secondary and primary prevention trials. In the secondary prevention trials (A), patients are at higher antecedent risk of a coronary event, and there appears to be a curvilinear relation, similar to the epidemiologic relation. In the primary prevention trials (B), with lower risk patients, the relation is much less steep. 4S = Scandinavian Simvastatin Survival Study; CARE = Cholesterol And Recurrent Events trial; LIPID = Long-term Intervention with Pravastatin in Ischemic Disease Study; WOSCOPS = West Of Scotland COronary Prevention Study; AFCAPS/TexCAPS = Air Force Coronary/Texas Atherosclerosis Prevention Study. P = placebo; T = treatment.