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Figure 3 ET-1-mediated inhibition of genomic DNA fragmentation in cardiac myocytes. Genomic DNA was isolated from myocytes maintained for 48 h in serum-free media in the presence or absence of Iso (10^–5 mol/liter) and ET-1 (10^–7 mol/liter) as indicated and loaded on a 1.5% agarose gel. M, molecular marker.