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Figure 1 ET-1-mediated inhibition of Iso-induced apoptosis in cultured neonatal rat cardiac myocytes. TUNEL-stained myocytes. (A) In the absence of Iso or ET-1; (B and C) in the presence of Iso (10^–5 mol/liter); (D) in the presence of Iso plus ET-1 (10^–7 mol/liter). Terminal deoxytransferase was omitted in C. Arrows show cells with evidence of apoptosis, including chromatin condensation.