Click on image to view larger version.

Figure 4 Rates of H⁺ production from glucose metabolism in untreated control (open bar) and hypertrophied (solid bar) hearts and DCA-treated control (hatched bar) and hypertrophied (stippled bar) hearts during preischemic perfusion (Before Ischemia) and reperfusion after ischemia (Reperfusion) (n = 6 to 13 per group). Significant differences (p < 0.05) are indicated as *versus untreated preischemic control hearts; #versus untreated preischemic hypertrophied hearts; versus reperfused untreated control hearts; versus reperfused untreated hypertrophied hearts. H⁺ production arising from glucose metabolism was calculated by subtracting the rate of glucose oxidation from the rate of glycolysis and multiplying by 2 (9).