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Figure 4 Comparison of TACE (a) and TNF-alpha (b) mRNA expressions in two myocarditis subgroups classified according to maximal CK concentration levels. TACE and TNF-alpha expression levels were significantly higher in the subgroup with CK >500 IU/liter than in the subgroup with CK <500 IU/liter (TACE/GAPDH ratio 3.84 ± 0.57 vs. 1.04 ± 0.20, p = 0.006; TNF-alpha/GAPDH ratio 5.29 ± 0.62 vs. 2.12 ± 0.42, p = 0.001).