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Figure 1 Change (means ± SEM) in flow-mediated dilation (FMD, %) from pretreatment values after release of 1, 3 and 5 min of arterial occlusion in patients treated with placebo (closed squares), sildenafil 12.5 mg (open squares), sildenafil 25 mg (open circles) and sildenafil 50 mg (open triangles).