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Figure 2 Mild hypothermia for cerebral resuscitation in patients with out-of-hospital cardiac cause of arrest. As a cooling method, coil cooling, which cools the blood circuit of continuous hemodiafiltration directly was used. As core temperature, pulmonary arterial blood temperature was monitored continuously by using a balloon flotation right-heart catheter. Induction and rewarming were conducted by two step down and slow step up methods, respectively. Hypothermia (34°C) at cooling stage continued for at least two days. Midazolam and pancuronium were used for anesthesia during this period, and nafamostat mesilate was used for control of coagulant.