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Figure 3 Representative recordings of (A) pH_i and (B) cell contraction in human ventricular myocytes from recipient hearts with end-stage heart failure during two consecutive acid pulses. The first acid pulses (open symbols) were under control conditions whereas during the second acid pulses (solid symbols) HOE-642 (1 µmol/L) was present during exposure to NH₄Cl and the first 7 min of NH₄Cl washout, as indicated by the horizontal bars. The baseline changes in (B) reflect changes in resting cell length. pH_i = intracellular pH.