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Figure 1 Study design. Open square = clinical and echocardiographic examination; Open circle = troponin I, creatine kinase (CK) and CK-MB mass determination. EC = epirubicin and cyclophosphamide; ICE = ifosfamide, carboplatin and etoposide; SEQ = sequential therapy (see Table 1); TEC = taxotere, epirubicin and cyclophosphamide; TICE = taxotere, ifosfamide, carboplatin and etoposide.