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Figure 1 (a) Effects of 8-Cl-cAMP (1, 5, and 10 µmol/liter) on the growth inhibition of rat VSMCs. Both 5 and 10 µmol/liter 8-Cl-cAMP induced a significant inhibition of VSMC proliferation at any time. (b) Western blot analysis in VSMCs untreated (control) or treated with 8-Cl-cAMP (1, 5, and 10 µmol/liter). The 8-Cl-cAMP induced a significant reduction of RI level, enhanced level of RII_ß, and showed no effect on catalytic subunit (c).