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Figure 2 Mean changes from baseline in standing systolic (A) and diastolic (B) BP after ISMN administration. Sildenafil plus ISMN caused significant decreases in systolic and diastolic BP compared with placebo plus ISMN. Oral ISMN (20 mg) and oral sildenafil (50 mg) or placebo were administered at time 0, as indicated by the arrows. Baseline (time 0) is the average of the measurements taken immediately before sildenafil or placebo administration. Values represent mean ± SEM; n = 16; BP = blood pressure; ISMN = isosorbide mononitrate.